A selection of recent and historical contributions by the Barnett Institute to the field of bioanalysis.

 Comprehensive Analysis of Proteins
• Extended Range Proteomic Analysis: high sequence coverage of large proteins, including characterization of glycosylation and phosphorylation.
• Multiple Lectin Affinity Chromatography (MLAC): Rapid isolation of glycoproteins, the most biomedically relevant class of proteins for biomarker discovery.
• CE-MS analysis of protein microheterogeneity. 

Clinical Proteomics
• Discovery of biomarkers for breast, cervical, and lung cancer.
• Antibody-based technologies for biomarker discovery and diagnostics.
• Human Proteome Organization (HUPO) Reference Lab.
• Editor in Chief, Journal of Proteome Research (ACS).

Additional Contributions
• Protein solution structure and dynamics by hydrogen-deuterium exchange MS.
• Post-translational modifications of proteins and DNA by biochemical tagging and mass spectrometry.
• Microscale LC-MS-NMR for metabolites and natural products.
• Reagents and methods for detection of DNA adducts.
• Environmental Cancer Research Program.

Past Successes

• Genome Sequencing: Key technologies used to sequence the human genome: microcapillary gel electrophoresis and linear polymer sieving matrices.
• HPLC: Major contributions to the development and acceptance of liquid chromatography, currently a multi-billion dollar industry.
• Capillary Electrophoresis: 
    Screening of natural product extracts for new therapeutic compounds using capillary electrophoresis.  
    Detection of rare single nucleotide mutations in DNA pooled from populations.
• LC-MS: Electrospray mass spectrometry from a microfluidic device.