The Barnett Gazette
Electronic Edition, Autumn 2009
This email highlights breaking news and events between mailings; you may follow links below for full stories on the Barnett Institute website. We hope you can take pride in the Institute’s continued success in a changing climate, as we do of our alumni and colleagues. Please let us know in turn of your activities and interests - Stay in Touch with your mentor, or Roger Kautz.
| In This Issue | ||
Alumni News
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New Directions Faculty and Research Updates |
Events Barnett Lectures: Saferstein Lectures: |
Alumni Interviews:
Visit the Alumni Pages for more news, and |
New Directions in the Institute Biopharmaceutical AnalysisPublication of many new methods of protein analysis (updates below), together with last year’s Biogenerics conference, has generated many collaborations on the analysis of protein pharmaceuticals and a memorandum of understanding with the FDA. The first Short Courses in State-of-the-Art Protein Analysis and Regulatory Science were taught in September. Their success, in terms of high attendance, FDA participation and positive reviews, is a go-ahead to offer a Professional Science Masters in Regulatory Analysis. The PSM is a new class of terminal degree, which combines hands-on laboratory science with professional skills in communication, legal, business, and management; focussed on the goal of bringing a bachelors-educated scientist or recruit into a professional capacity in two years. The rapidly increasing interest in protein analysis methods also supports the longer-range plan for a Center for Advanced Regulatory Analysis (CARA). CARA would be a center of excellence with facilities to develop and validate new analytical methods for QA and PAT; a GLP lab is planned. CARA would also meet demands for an academy capable of training GLP staff for industry, and regulatory scientists for the FDA. |
Recent Events
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The 2009 Saferstein Lectures "Don't believe anything you see on CSI ! " |
Faculty and Research Updates
Barry Karger continues to lead significant advances in the analysis of complex proteins, with recent applications demonstrating more comprehensive characterization of complex proteins using a combination of ETD with CID and "middle down" proteomic analysis, as well as trace-level analysis using ultranarrow bore chromatography. Recent papers include profiling glycoforms with CE-MS and mapping S-S bonding.
William Hancock remains active in the study of glycoproteomics
and glycans associated with infectious disease, and heads a major NIH program investigating glycans as cancer biomarkers. Recent papers include glycoproteome changes in breast cancer and rheumatoid arthritis. In biopharmaceutical analysis, he reports a proteomic analysis of high-producing CHO cultures, an analysis of innovator, counterfeit, and follow-on rhGH and methods for pharmokinetics of protein drugs.
Paul Vouros has deferred retirement with another round of grants: in metabolomics, DNA adducts, and toxicogenomics. Recent papers describe how cytosine methylation modulates benzopyrene adduction, LC-MS-NMR identification of active cyanobacterial metabolites , and profiling of the circulating endocannabinoid metabolome.
Roger Giese is also active in the detection and identification of trace
biomolecules such as genotoxins, DNA adducts, steroids, and bio-active
peptides. He heads the Environmental Cancer Research Program. and has published recently on (PCI)-like behavior of estradiol in MALDI and purification of a phospholipase from Pallas viper venom
Graham Jones group is dedicated to the application of synthetic organic chemistry to the development of diagnostic and therapeutic agents. His work includes targeted delivery and activation of cytotoxic antitumor agents and rapid synthetic methods to incoporate radiolabels for SPECT and PET imaging.
Sunny Zhou’s new methodologies to characterize protein post-translational modifications are finding valuable applications in autoimmunity and metabolic diseases. He recently reported a naturally-occuring agent that covalently inactivates LuxS.
John Engen characterizes protein conformation using hydrogen/deuterium exchange mass spectrometry. He recently received the prestigious Arthur F. Findeis Award for Achievements by a Young Analytical Scientist from the American Chemical Society, and had a feature article and cover story on HX-MS in Analytical Chemistry.
Bill Giessen is still active applying advanced chemometric methods to market analysis.
Andras Guttman has joined the Institute. Previously a Marie Curie Chair of the European Commission, Andraj has expertise in glycomics and glycoproteomics, using techniques of capillary electrophoresis, mass spectrometery, and microchips. He recently reported a monolithic support for a trypsin nanoreactor.
Roger Kautz uses microscale NMR with droplet microfluidics for LC-MS+NMR applications in natural product discovery and metabolomics. He recently published work on NMR detection of apoptosis in live cells, and received a grant to outfit the 700 MHz NMR with microcoil techonology.
Tomas Rejtar recently published exciting applications of CE-MS of glycoproteins, and the stability of the HIV TAT peptide.
Stay in Touch
Tell us about your activities and interests: contact your mentor, or Roger Kautz.
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