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Professor William S. Hancock's Research GroupProfessor Hancock's research group is directed at the study of disease mechanisms and discovery of potential therapeutic agents by proteomic analysis of biological fluids and tissues samples. This area has been termed clinical proteomics. The proteomic analysis is performed by an approach known as shotgun sequencing in which a sample is digested with a proteolytic enzyme and the resulting complex peptide mixture is separated by HPLC. The identity of the peptide is determined by on-line mass spectrum (ion trap or Fourier transform), using MS/MS fragmentation patterns and accurate mass measurements. The corresponding protein(s) is (are) then identified by searching of genomic and proteomic databases and in a typical analysis of plasma or cerebrospinal fluid several hundred proteins may be identified. Professor Hancock's
Research Group Members Research Associate Professor Research Assistant Professor Graduate Students
Projects Multi-Lectin Affinity Columns Novel LC-MS and Gel LC-MS Plattforms for the Characterization of Therapeutic Monoclonal Antibodies Poster.pdf (Wang, ASMS 2009 Glycoproteome Changes in Breast Cancer: Identification by Multi-lectin Affinity Chromatography (M-LAC) combined with digital ProteomechipTM (dPCTM) and Mass Spectrometry Poster.pdf (Zeng, MSB 2009) Proteomic Analysis of Human Pulmonary Artery Endothelial Cells using nano-LC-MS/MS Poster.ppt (Baker, ASMS 2005) |
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