Contributions

Significant Advances and other Honors

The Institute has contributed many technologies that have become standard in bioanalysis

Recent Contributions

  Comprehensive Analysis of Proteins
  • Extended Range Proteomic Analysis: high sequence coverage of large proteins,
     including characterization of glycosylation and phosphorylation.
  • Multiple Lectin Affinity Chromatography (MLAC): Rapid isolation of glycoproteins, the most      biomedically relevant class of proteins.
  • CE-MS analysis of protein microheterogeneity.

  Clinical Proteomics
  • Discovery of biomarkers for breast, cervical, and lung cancer.
  • Antibody-based technologies for biomarker discovery and diagnostics.
  • Human Proteome Organization (HUPO) Reference Lab.
  • Editor in Chief, Journal of Proteome Research (ACS).

Additional Contributions

  • Protein solution structure and dynamics by hydrogen-deuterium exchange MS.
  • Post-translational modifi cations of proteins and DNA by biochemical tagging and mass spectrometry.
  • Microscale LC-MS-NMR for metabolites and natural products.
  • Reagents and methods for detection of DNA adducts.
  • Environmental Cancer Research Program.

Past Successes
  • Genome Sequencing: Key technologies used to sequence the human genome:
      microcapillary gel electrophoresis and linear polymer sieving matrices.
  • HPLC: Major contributions to the development and acceptance of liquid chromatography,
     currently a multi-billion dollar industry.
  • Capillary Electrophoresis: Screening of natural product extracts for new therapeutic
     compounds using capillary electrophoresis. Detection of rare
     single nucleotide mutations in DNA pooled from populations.
  • LC-MS: Electrospray mass spectrometry from a microfluidic device.