Recent Papers

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Rand KD, Pringle SD, Murphy JP, Fadgen KE, Brown J, Engen JR. Profiling the lGas-Phase Hydrogen/Deuterium Exchange in a Traveling Wave Ion Guide for the Examination of Protein Conformations. Anal Chem. 2009 Nov 18. [Epub ahead of print]. (pubmed)

Zang T, Dai S, Chen D, Lee BW, Liu S, Karger BL, Zhou ZS. Chemical methods for the detection of protein N-homocysteinylation via selective reactions with aldehydes. Anal Chem. 2009 Nov 1;81(21):9065-71.(pubmed)

Thakur D, Rejtar T, Karger BL, Washburn NJ, Bosques CJ, Gunay NS, Shriver Z, Venkataraman G. Profiling the Glycoforms of the Intact alpha Subunit of Recombinant Human Chorionic Gonadotropin by High-Resolution Capillary Electrophoresis-Mass Spectrometry. Anal Chem. 2009 Nov 1;81(21):8900-7. (pubmed)

Lu Q, Zheng X, McIntosh T, Davis H, Nemeth JF, Pendley C, Wu SL, Hancock WS. Development of Different Analysis Platforms with LC-MS for Pharmacokinetic Studies of Protein Drugs. Anal Chem. 2009 Nov 1;81(21):8715-23. (pubmed)

Bell AW,et al. A HUPO Test Sample Study Reveals Common Problems in Mass Spectrometry-Based Proteomics. Nat. Methods 2009 6(6), 423-30. (pubmed)

Taylor AD, Hancock WS, Hincapie M, Taniguchi N and Hanash SM Towards an Integrated Proteomic and Glycomic Approach to Finding Cancer Biomarkers. Genome Med., 2009 Jun 4, 1(6):57. (pubmed)

Zeng Z, Hincapie M, Haab BB, Hanash S, Pitteri SJ, Kluck S, Hogan JM, Kennedy J, Hancock WS.  The development of an integrated platform to identify breast cancer glycoproteome changes in human serum. J Chromatogr A. 2009 Sep 16. [Epub ahead of print] (pubmed)

Zang T, Lee BW, Cannon LM, Ritter KA, Dai S, Ren D, Wood TK, Zhou ZS. A Naturally Occurring Brominated Furanone Covalently Modifies and Inactivates LuxS. Bioorg Med Chem. Lett. 2009, 21, 6200-6204 pubmed

Musacchio T, Toniutti M, Kautz R, Torchilin V. 1H NMR detection of mobile lipids as a marker for apoptosis: The case of anti-cancer drug-loaded liposomes and polymeric micelles.Mol Pharm. 2009 Sep 9. [Epub ahead of print] (pubmed)

Akella LM, Rejtar T, Orazine C, Hincapie M, Hancock WS  "CLUE-TIPS, Clustering Methods for Pattern Analysis of LC-MS Data" J Proteome Res. 2009 Oct;8(10):4732-42. (pubmed)

Grunwald J, Rejtar T, Sawant R, Wang Z, Torchilin VP. TAT Peptide and Its Conjugates: Proteolytic Stability.  Bioconjug Chem. 2009 Jul 14. [Epub ahead of print] (pubmed)

Wang P, Kremsky JN, Giese RW. Positive chemical ionization (PCI)-like behavior of estradiol in matrix-assisted laser desorption/ionization. Rapid Commun Mass Spectrom. 2009 Sep;23(17):2836-8. (pubmed)

Carlage T, Hincapie M, Zang L, Lyubarskaya Y, Madden H, Mhatre R, Hancock WS. Proteomic profiling of a high-producing chinese hamster ovary cell culture. Anal Chem. 2009 Sep;1;81(17):7357-62. (pubmed)

Jia Y, Wu SL, Isenberg JS, Dai S, Sipes JM, Field L, Zeng B, Bandle RW, Ridnour LA, Wink DA, Ramchandran R, Karger BL, Roberts DD. Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. Cell Stress Chaperones.2009 1355-8145. (link)

LaBeaume P, Wager K, Falcone D, Li J, Torchilin V, Castro C, Holewa C, Kallmerten AE, Jones GB. Synthesis, functionalization and photo-Bergman chemistry of enediyne bioconjugates. Bioorg Med Chem. 2009 Sep 1;17(17):6292-300. Epub 2009 Jul 26. pubmed

Monzo A, Rejtar T, Guttman A.  Optimization of poly(GMA-co-EDMA) Monolithic Support for Trypsin Nanoreactor Fabrication. J Chromatogr Sci. Jul 2009; 47(6):467-72. (pubmed)

Glick J, Xiong W, Lin Y, Noronha AM, Wilds CJ, Vouros P.  The influence of cytosine methylation on the chemoselectivity of benzo[a]pyrene diol epoxide-oligonucleotide adducts determined using nanoLC/MS/MS. J Mass Spectrom. 2009 Aug;44(8):1241-8 (pubmed)

Karger BL, Guttman A.  DNA sequencing by CE. Electrophoresis, Jun 2009; 30 Suppl 1:S196-202.(pubmed)

Lazarev AV, Rejtar T, Dai S, Karger BL. Centrifugal methods and devices for rapid in-gel digestion of proteins. Electrophoresis. Mar 2009; 30(6):966-73. (pubmed)

Ma D, Lin Y, Xiao Z, Kappen L, Goldberg IH, Kallmerten AE, Jones GB. Designed DNA probes from the neocarzinostatin family: impact of glycosyl linkage stereochemistry on bulge base binding. Bioorg Med Chem. 2009 Mar 15;17(6):2428-32. Epub 2009 Feb 10. (pubmed)

Jiang H, Wu SL, Karger BL, Hancock WS.  Mass spectrometric analysis of innovator, counterfeit, and follow-on recombinant human growth hormone. Biotechnol Prog. Jan-Feb 2009; 25(1):207-18. (pubmed)

Zheng X, Wu SL, Hincapie M, Hancock WS. Study of the human plasma proteome of rheumatoid arthritis.   J Chromatogr A. Apr 17 2009,1216(16):3538-45. (pubmed)

Iacob RE, Pene-Dumitrescu T, Zhang J, Gray NS, Smithgall TE, Engen JR. Conformational disturbance in Abl kinase upon mutation and deregulation. Proc Natl Acad Sci USA. Feb 2009; 106(5):1386-912009 (link)

Wu, Shiaw-Lin; Jiang, Haitao ; Lu, Qiaozhen ; Dai, Shujia ; Hancock, William S. and Karger, Barry L.   Mass Spectrometric Determination of Disulfide Linkages in Recombinant Therapeutic Proteins Using Online LC-MS with Electron-Transfer Dissociation   Anal. Chem.   2009 81(1):112-22   (link)

Lin Y, Schiavo S, Orjala J, Vouros P, Kautz R. Microscale LC-MS-NMR platform applied to the identification of active cyanobacterial metabolites. Anal Chem. 2008 80(21):8045-8054. (link)

Luo Q, Rejtar T, Wu SL, Karger BL Hydrophilic interaction 10mum I.D. porous layer open tubular columns for ultratrace glycan analysis by liquid chromatography-mass spectrometry. J Chromatogr A. Feb 2009;1216(8):1223-31 (pubmed)

Chen S, O'Reilly LP, Smithgall TE, Engen JR Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core. J Mol Biol. 2008 383(2):414-23 (pubmed)

Jones GB, Lin Y, Ma D, Xiao Z, Hwang GS, Kappen L, Goldberg IH. Congeners of the enediyne neocarzinostatin chromophore: designed agents for bulged nucleic acid targets. Curr Top Med Chem. 2008;8(6):436-47. (pubmed)

Iacob RE, Murphy JP 3rd, Engen JR. Ion mobility adds an additional dimension to mass spectrometric analysis of solution-phase hydrogen/deuterium exchange. Rapid Commun Mass Spectrom. 2008 22(18):2898-904 (pubmed)

Dai S, Jia Y, Wu SL, Isenberg JS, Ridnour LA, Bandle RW, Wink DA, Roberts DD, Karger BL. "Comprehensive Characterization of Heat Shock Protein 27 Phosphorylation in Human Endothelial Cells Stimulated by the Microbial Dithiole Thiolutin."  J Proteome Res. Aug 23 2008, . 7(10):4384-95   pubmed 

Baumgartner C, Rejtar T, Kullolli M, Akella LM, Karger BL. "SeMoP: A New Computational Strategy for the Unrestricted Search for Modified Peptides Using LC-MS/MS Data." J Proteome Res. 7(9):4199-4208. (2008)   pubmed 

Alfaro JF, Gillies LA, Sun HG, Dai S, Zang T, Klaene JJ, Kim BJ, Lowenson JD, Clarke SG, Karger BL, Zhou ZS.   "Chemo-enzymatic detection of protein isoaspartate using protein isoaspartate methyltransferase and hydrazine trapping. "    Anal Chem. 80(10):3882-9  (2008)   pubmed 

Luo Q, Gu Y, Wu SL, Rejtar T, Karger BL.  "Two-dimensional strong cation exchange/porous layer open tubular/mass spectrometry for ultratrace proteomic analysis using a 10 microm id poly(styrene- divinylbenzene) porous layer open tubular column with an on-line triphasic trapping column."  Electrophoresis. 29(8):1604-11. (2008)    pubmed 

Wood JT, Williams JS, Pandarinathan L, Courville A, Keplinger MR, Janero DR, Vouros P, Makriyannis A, Lammi-Keefe CJ.  "Comprehensive profiling of the human circulating endocannabinoid metabolome: clinical sampling and sample storage parameters."  Clin Chem Lab Med. 2008 Jul 8. [Epub ahead of print]   pubmed

Wales TE, Fadgen KE, Gerhardt GC, Engen JR. High-speed and high-resolution UPLC separation at zero degrees Celsius. Anal Chem. 2008 80(17):6815-20. pubmed

Schiavo S, Ebbel E, Sharma S, Matson W, Kristal BS, Hersch S, Vouros P. Metabolite identification using a nanoelectrospray LC-EC-array-MS integrated system. Anal Chem. Aug 2008; 80(15):5912-23. pubmed

Wang Y, Cui G, Zhao M, Yang J, Wang C, Giese RW, Peng S.Bioassay-directed purification of an acidic phospholipase A(2) from Agkistrodon halys pallas venom. Toxicon. 2008 Jun 1;51(7):1131-9. Epub 2008 Jan 17. pubmed

Falcone D, Li J, Kale A, Jones GB. Photoactivated enediynes as targeted antitumoral agents: efficient routes to antibody and gold nanoparticle conjugates. Bioorg Med Chem Lett. 2008 Feb 1;18(3):934-7. Epub 2008 Jan 7. (pubmed)

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